Биологический каталог




Иммунология. Том 3

Автор У.Пол

ориоменингита (ВЛХМ) [55]. У нормальных животных

ВЛХМ

ВЛХМ

8 дней

Цитоксан (иммуносупрессия)

Жива, но "несет вирус

Рис. 25.7. Эксперименты, указывающие на то, что патологические симптомы инфекции вирусом лимфоцитарного хориоменингита вызваны цитотоксическими Т-клетками, направленными против вируса [55].

ВЛХМ

Цитоксан

Смерть с классической патологией ЛХМ

Цитотоксические Т-лимфоциты

после этого возникает острое воспаление сосудистого сплетения, эпендимы, мягкой и паутинной оболочек мозга, и такие мыши умирают через 6—8 дней от полного разрушения ткани мозговых оболочек. Иммуносупрессированные мыши, зараженные этим вирусом, по продолжительности жизни не отличаются от незараженных, хотя в течение всей жизни в их мозговых оболочках обнаруживается вирус. При введении таким животным нормальных Т-клеток они быстро умирают, обнаруживая классическую патологию, характерную для животных, зараженных ВЛХМ [55]. На рис. 25.7 эти результаты показаны в схематическом виде. Очевидно, образование в организме хозяина ЦТЛ, направленных к ВЛХМ, вызывает разрушение тканей, несущих этот вирус, что и приводит к разрушению мозговых оболочек.

Итак, имеется много указаний на то, что цитотоксические клетки — это важный компонент иммунной системы млекопитающих, но условия, в которых проявляется действие разных категорий цитотоксических клеток, требуют уточнения. Появление новой технологии, позволяющей длительно культивировать и клонировать цитотоксические клетки, должно значительно ускорить эту работу.

ЛИТЕРАТУРА

1. GovaertsA . Cellular antibodies in kidney homotransplantation, J. Immunol., 85,516 (1960).

2. Cerrottini J. C., Brunner К. T. Cell-mediated cytotoxicity, allograft rejection and tumor immunity, Adv. Immunol., 18, 67 (1974). К. С. Хэнни, С. Джиллис

3. Zinkernagel R. М., Doherty Р. С. Restriction of an in vitro T cellmediated cytotoxicity in lymphocyte choriomeningitis within syngeneic or semiallogeneic system, Nature, 248, 701 (1974).

4. Brunner К. Т., Much J., Cerottini J.-C, Charuis B. Quantitative assay for the lytic action of immune lymphoid cells on "Cr labelled allogeneic target cells in vitro, Immunology, 14, 181 (1968).

5. Henney C. S. Quantitation of the cell-mediated response. I. The number of cytolytically active mouse lymphoid cells induced by immunization with allogeneic mastocytoma cells, J. Immunol., 116, 146 (1971).

6. Henney C. S. Studies on the Mechanism of T cell cytolysis, Transplant. Rev., 17, 37 (1973).

7. Berke G., Amos D. B. Studies on the mechanism of lymphocyte-mediated cytolysis and its role in transplantation immunity, Transpant. Rev., 17, 71 (1973).

8. Martz E. Mechanism of tumor-cell lysis by T lymphocytes, Contemp. Top. Immunobiol., 7, 301 (1977).

9. Zagury D., Bernard J., Thierness N., Feldman M., Berke G. Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes: Conjugation, killing and recycling at the single cell level, Eur. J. Immunol., 5, 818 (1975).

10. Stulting R. D., Berke G. Nature of lymphocyte-tumor interaction. A general method for cellular immunoadsorption, J. Exp. Med., 137, 932 (1973).

11. Werkele H., Lonai P., Feldman M. Fractionation of antigen-reactive cells on a cellular immunoadsorbent: Factors determining recognition of antigens by T lymphocytes, Proc. Natl. Acad. Sci. USA, 69, 1620 (1972).

12. Henney C. S., Bubbers J. E. Antigen-T lymphocyte interactions: Inhibition by cytochala-sin B, J. Immunol., Ill, 85 (1973).

13. Martz E. Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization, J. Immunol., 115, 261 (1975).

14. Golstein P., Smith E. T. The lethal hit stage of mouse T and not-T cell-mediated cytolysis: Differercos in cation requirements and characterization of an analytical «cation pulse* method, Eur. J. Immunol., 6, 31 (1976).

15. Plaut M., Bubbers J. E., Henney C. S. Studies on the mechanism of lymphocyte-mediated cytolysis. VII. Two stages in the T cell-mediated lytic cycle with distinct cation requirements, J. Immunol., 116, 150 (1976).

16. Golstein P., Shortman К., MacLennan I. С. M. Mechanism of recognition by cytolytic T cells, J. Supramol. Struct. (Suppl.), 3, 309 (Abstract) (1979).

*7. Moller E. Contact-induced cytotoxicity by lymphoid cells containing foreign isoantigens,

Science, 147, 559 (1965). 18. Kuppers R. C, Henney C. S. Evidence for direct linkage between antigen recognition and

lytic expression in effector T cells, J. Exp. Med., 143, 684 (1976). J9. Golstein P. Sensitivity of cytotoxic T cells on T cell-mediated cytotoxicity, Nature, 252, 81 (1974).

•20. Fishelson Z., Berke G. T lymphocyte-mediated cytolysis: Dissociation of the binding and lytic mechanisms of the effector cell, J. Immunol., 120, 1121 (1978).

21. Henney C. S. T-cell mediated cytolysis: An overview of some current issues, Contemp. Top. Immunobiol., 7, 245 (1977).

22. Granger G. A., Kolb W. P. Lymphocyte in vitro cytotoxicity', J. Immunol., 101, 111 (1968).

23. В alias Z. K., Henney C. S. Relationship between lymphokines and cell-mediated toxicity. In: Biology of Lymphokines, ed. by E. Pick, J. Oppenheim, and S. Cohen, pp. 165, Academic Press, New York, 1979.

24. Ferluga J., Allison A. C. Cytotoxicity of isolated plasma membranes from lymph node

cells, Nature, 255, 708 (1975).

25. Kahn-Perles В., Golstein P. Cell-membrane-mediated cytolysis by membranes from noncyto-

lytic cells, Eur. J. Immunol., 8, 71 (1978).

26. Frye L. D., Friou G. J. Inhibition of mammalian cytotoxic cells by phosphatidilcholine and its analogue, Nature, 258, 333 (1975).

27. Henney C. S. Studies on the mechanism of lymphocyte mediated cytolysis. II. The use of various target cell markers to stady cytolytic events, J. Immunol., 110, 73 (1973).

28. Henney C. S. Estimation of the size of a T cell induced lytic lesion, Nature, 249, 456 (1974).

29. Morgan D.A., Ruscetti F. W., Gallo R. C. Selective in vitro growth of T lymphocytes from normal human bone marrow, Science, 193, 1007 (1976).

30. Srendi В., Schwartz R. H. Antigen specific, proliferating T cell clones. Methodology, specificity, MHC restriction and alloreactivity, Immunol. Rev., 54, 187 (1981).

31. Okada M., Klimpel G. R., Kuppers R. C, Henney C. S. The differentiation of cytotoxic T cells in vitro. I. Amolifying factor(s) in the primary response are Lyt 1+ cell dependent, J. Immunol., 122, 2527 (1979).

25. Клеточная цитотоксичность 32. Shaw J., Caplan В., Paetkau V., Pilarski P. L. M., Delovitch T. L., McKenzie I. F. C. Cellular origins of costimulator (IL-2) and its activity in cytotoxic T lymphocyte responses, J. Immunol., 124, 2231 (1980).

33. Watson J., Gillis S., Marbrook J., Mochizuki D., Smith K. A. Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines, J. Exp. Med., 150, 849 (1979).

34. Gillis S., Scheid M., Watson J. Biochemical and biological characterization of lymphocyte regulatory molecules. III. The isolation and phenotypic characterization of Interleukin 2 producing T cell lymphomas, J. Immunol., 125, 2570 (1980).

35. Gillis S., Gillis A. E., Henney C. S. Monoclonal antibody directed against Interleukin-2.

I. Inhibition of T-lymphocyte mitogenesis, and the in vitro differentiation of alloreactive cytolytic T-cells, J. Exp. Med., 154, 983 (1981).

36. Smith K. A., Gillis S., Baker P. E., McKenzie D., Ruscetti F. W. T cell growth factor-mediated T cell proliferation, Proc. N. Y. Acad. Sci., 332, 423 (1979).

37. Kern D. E., Gillis S., Okada M., Henney C. S. The role of interleukin-2 (IL-2) in the differentiation of cytotoxic T cells: The effect of monoclonal anti-IL-2 antibody and absorption with IL-2 dependent T cell lines, J. Immunol., 127, 1323 (1981).

38. Farrar W. L., Johnson H. M., Farrar J. J. Regulation of the production of immune interferon and cytotoxic T lymphocytes by Interleukin 2, J. Immunol., 126, 1120 (1981).

39. Larsson E. L., Iscove N. N., Coutinho A. Two distinct factors are required for induction of T cell growth, Nature, 283, 664 (1980).

40. Herberman Л., ed. Natural Cell Mediated Immunity Against Tumors, Academic Press, New York, 1980.

41. Dennert G., Yogeeswaran G., Yamagata S. Cloned cell lines with natural killer activity, specificity, function, and cell surface markers, J. Exp. Med., 153, 545 (1981).

42. Brooks C. G., Kuribayashi K., Sale G. E., Henney C. S. Characterization of five cloned murine cell lines showing high cytolytic activity against YAC-1 cells, J. Immunol., 128, 2326 (1982).

43- Durdik J. M., Beck B. N., Henney C. S. The use of lymphoma cell variants differing in their susceptibility to NK cell mediated lysis to analyze NK cell-target cell interactions. In: Natural Cell-Mediated Immunity Agains Tumors, ed. by R. B. Herberman, pp. 805— 817, Academic Press, New York, 1980.

44. Quan G., Ishizaka Т., Bloom B. Studies on the mechanism of NK cell lysis, J. Immunol., 128, 1786 (1982).

45. Moller E. Contact-induced cytotoxicity by lymphoid cells containing foreign isoantigens, Science, 147, 873 (1965).

46. Perlmann P., Holm G. Cytotoxic effects of lymphoid cells in vitro. In: Advances in Immunology, Vol. 11, Academic Press, New York, 1969.

47. Segal I). M'., Hurwitz E. Binding of affinity cross-linked oligomers of IgG to cells bearing Fc receptors, J. Immunol., 118, 1338 (1977).

48. Ziegler H. K., Henney C. S. Studies on the cytotoxic activity of human lymphocytes.

II. Interactions between IgG and Fc receptors leading to inhibition of К cell function, J. Immunol., 119, 1010 (1977).

49. Reid L. M., Minato N., Gresser I., Holland J., Kadish A., Bloom B. R. Influence of anti-mouse interferon serum on the growth and metastasis of tumor cells persistently injected with virus and of human prostatic tumor

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