. 2

., .

HIS GLY VAL LEU ASN PRO THR TYR GLN ALA GLY LEU ARG ARG ASP ALA VAL GLN PRO

CT0TCCACGGAGT6CTTAATCCAACTTACCA A G T GGGTTACGACOCGACGCCGTTCAAC

S187 5197 5207 A1J/5 5217 5227 5237

A GLN ILE LEU LYS GLN ASN ALA LYS ARG GLU MET ARG LEU ARG LEU GLY LYS VAL THR VAL

ASP ILE GLU ALA GLU ARG LYS LYS ARG ASP GLU ILE GLU ALA GLY LYS SER TYR CYS SER

CAGATATTGAAGCAGAACGCAAAAAGAGAGATGAGATTGAGGCTGGGAAAAGTTACTGTA

5247 5257 5247 5277 5297 5297

ALA ASP UAL LEU ALA ALA GLN PRO VAL THR THR ASN LEU LEU LYS PHE MET AKG ALA SER

t ARG ARG PHE GLY GLY ALA THR CYS ASP ASP LYS SER ALA GLN ILE TYR ALA ARG PHI ASP

GCCGACGTTTTGGCG G G AACCTGTGACGACAAATCTGCTCAAATTTAT G G G T T 6

5307 5317 5327 t 5337 5347 ~~ 5:iL,7

hi/is His/ Tj/7

A ILE LYS MET ILE GLY VAL SER ASN LEU GLN SER PHE ILE ALA SER MET THR GLN LYS LEU

LYS ASN ASP TRP ARG ILE GLN PRO ALA GLU PHE TYR ARG PHE HIS ASP ALA GLU VAL ASN

ATAAAAATGATTGGCGTATCCAACC T G A G AGTTTTATCSCTTCCATGACGCAGAA G T T A

5347 3377 1 II 21 3?

W/l R5/7b

A THR LEU SER ASP ILE SER ASP GLU SER LYS ASN TYR LEU ASP LYS ALA GLY ILE THR THR

MET SER ARG LYS ILE ILE LEU ILE LYS GLN GLU LEU LEU LEU

THR PHE GLY TYR PHE **

ACTTTCGGATATTTCTGAT T G A AAAATTATCTTGATAAAGCAGGAATTACTACT

41 51 /, tJ/, 41 71 81 91

ALA CYS LEU ARG ILE LYS SER LYS TRP THR ALA GLY GLY LYS ***

LEU U*L TYR GLU LEU ASN ARG SER GLY LEU LEU ALA GLU ASN GLU LYS ILE ARG PRO ILE

MET ARG LYS PHE ASP LEU SEI;

GCTTGTTTACGAAITAAA T G A AGTGGACTGCTGGCGBAAAATGAGAAAAT T G T A T

.01 lll>/f 121 131 141 I9/l0 151

LEU ALA GLN LEU GLU LYS LEU LEU LEU CYS ASP LEU SER PKO SER THR ASN ASP SER VAL

LEU ARG SER SER ARG SER SER TYR PHE ALA THR PHE ARG HIS GLN LEU THR ILE LEU SEF

T I 6CGCAGCTCGA G A A G T CTTACTTTGCGACCTTTCGCCATCAACTAAC G A T T T G T

161 171 181 191 301 M/n 211

?aw* A5/I /* AIS/6 F"'1J

LYS ASN **

LYS 1 ASP ALA LEU ASP GLU GLU LYS TRP LEU ASN MET LEU GLY THR PHE VAL LYS AS

CAAAAACTGACGCeTTGGATGAGGAGAAGTGGCTTAATATGCTTGGCACGTTCGTCAAGG

221 231 241 251 261 271

TRP PHE ARG TYR GLU SER HIS PHE VAL HIS GLY ARG ASP SER LEU VAL ASP ILE LEU LY

ACTGGTTTAGATAT 6 A G T E ACATTTTGTTCATGGTAG T T T T T G T T G A T T T T A A

13/17 7/16 R7b/6c

MET

GUI ARG GLY LEU LEU SER GLU SER ASP ALA VAL GLN PRO LEU ILE GLY LYS LYS SER *t

AAGAGCGTGGATTACTATCT G A G T C.G ATGCTGTTCAACCACTAATAGGTAAGAAATCAT

341 351 F16a/16b T 341 371 381 391

? scut I

SER GLN (ML THR GLU GLN SER VAL ARG PHE GLN THR ALA LEU ALA SER ILE LYS LEU ILE

G A G T AAGTTACTGAACAATCCGTACGTTTCCAGACCGCTTT G G T T A T T A A G CAT

rltb/1 401 411 421 431 Z3/7 441 6 4 = 1

GLN ALA SER ALA VAL LEU ASP LEU THR GLU ASP ASP PHE ASP PHE LEU THR SER ASN LYS

TCAGGCTTCTGCCGTTTTGGATTTAACC G A G A T G A T T T G A TTTTCTGACGAGTAACAA

461 471 481,,7 491 501 Ell

Ml/7 I4/5

VAL TRP ILE ALA THR ASP ARG SER ARG ALA ARG ARG CYS VAL GLU ALA CYS VAL TYR GLY

MET Vfl

*6TTT66ATTGCTACTGACCGCTCTCGTGCTCGTCGCTGCGTTGAGGCTTGCGTTTATG0

521 331 S41 551 541 571

THR LEU ASP PHE VAL GLY TYR PRO ARG PHE PRO ALA PRO VAL GLU PHE ILE ALA ALA VAL

ARG TRP THR LEU TRP ASP THR LEU ALA PHE LEU LEU LEU LEU SER LEU LEU LEU PRO SE

TACGCTGGACT TTGTGGGATACCC TCGCTTTCCTGCTCCTGTTGAGTTTATTGCTGCCGT

581 591 401 411 621 431

451

641

H4/13

ILE ALA TYR TYR VAL HIS PRO VAL ASN ILE GLN THR ALA CYS LEU ILE MET GLU GLY ALA LEU LEU ILE MET PHE ILE PRO SER THR PHE LYS ARG PfcO VAL SER SER TRP LYS ALA LE CATTGCTTA TTATGTTCATCC CG T ATTCAAAC G G TGTCTCATCATGGAAG G G

661 671 681

Z7/5

R6c/.7

GLU PHE THR GLU ASN ILE ILE ASN GLY VAL GLU ARG PRO VAL LYS ALA ALA GLU LEU PHE

ASN LEU ARG LYS THR LEU LEU MET ALA SER SER VAL ARG LEU LYS PRO LEU ASN CYS SE

TGAATTTACGGAAAACATTATTAATGGCG T G A G G T G TTAAAGCCGCTGAATTGTT

701 711 721 731 741 751

5/

ALA PHE THR LEU ARG VAL ARG ALA GLY ASN THR ASP VAL LEU THR ASP ALA GLU GLU ASN

ARG LEU PRO CYS VAL TYR ALA GLN GLU THR LEU THR PHE LEU LEU THR GLN LYS LYS Tr

CGCGTTTACCTTGCGTGTAC G G AGGAAACACTGACGTTCTTACT5ACGCA G ft A G A AAA

761 771 H13/U 781 791 801 M7/3 8U

MET .SER LYS GLY LYS LYS ARG SER

VAL ARG GLN LYS LEU ARG ALA GLU GLY VAL MET ***

CYS VAL LYS ASN TYR VAL ARG LYS GLU ***

CGTGCGTCAAAAATTACGTGCGGAAGGAGTGATGTAATGTCTAAAGGTAAAAAACGTTCT

821 831 841 851 861 871

GLY ftLA ARG PRO GLY ARG PRO GLN PRO LEU ARG GLY THR LYS GLY LYS ARG LYS GLY Al.A

G G TCGCCCTGGTCGTCCGEAGCCGTTGCGAGGTACTAAAGGCAAGCGTAAAG V, . . T

Hll/K B81 891 901 911 921 931

ARG LEU TRP TYR VAL GLY GLY GLN GLN PHE *** CGTCTTTGGTATGTAGGTG G T AATTTTAATTGCAGGGGCTTC G G . ,

941 951 , 961 971 9B1 99lT

R7*/6b /" Minor cam .nd 1

MET SER ASN ILE GLN THR GLY ALA GLU ARG MET PRO HIS ASP LEU SER HIS

GGATAAATTATGTCTAATATTCAAACTG G G CGAGCGTATGCCGCATGACCTTTCCCAT

1001 1011 1021 1031 1041 1051

H12/10

LEU GLY PHE LEU ALA GLY GLN ILE GLY ARG LEU ILE THR ILE SER THR THR PRO VAL ILE

CTTGGCTTCCTTGCTGGTCAGATTGGTCGrCTTATrACCATrTCAACTACT G T T A 7

1061 1071 1081 1091 1101 Y3/2 1111

ALA GLY ASP SER PHE GLU MET ASP ALA VAL GLY ALA LEU ARG LEU SER PRO LEU ARG ARB

G T G G G T T T A GATGGACGCCGTTG 6 TCTCCGTCTTTCTCCATTGCGTCGT

1121 1131 1141 , 1151 1141 1171

13/1 >

F BLY LEU ALA ILE ASP SER THR VAL ASP ILE

G G TTGCTATT G T TftCTGTAGACATI

Z3/4 IIBI FUb/2 1171 1201

PHE THR PHE TYR VAL PRO HIS ARG HIS VAL

TTTACTTTTTATGTCCCTCATCGTCACGTT

1211 1221 1231

TYR GLY GLU GLN TRP ILE LYS PHE LYS ASP GLY VAL ASN ALA THR PRO LEU PRO THR

TAT G G T G A ACAOTUGATTAAGTTCATBAAGGATGGTGTTAATGCCACTCCTCTCCCGACT

Ql/3c 1241 1251 I3*1 1271 1291 12,1

F VAL ASN THR THR GLY TYR ILE ASP HIS ALA ALA PHE LEU GLY THR ILE ASN PRO ASP THR

G T T ACTACTGGTTATATTGACCATGCCGCTTTTCTTGGCACGATTAAECCTGATACC

6b/l 1301 1311 1321 1331 1341 13S1

F ASN LYS ILE PRO LYS HIS LEU PHE GLN GLY TYR LEU ASN ILE TYR ASN ASN TYR PHE LYS

AATAAAATCCCTAAGCATTTGTTTCAOGGTTATTTGAATATCTATAACAACTATTTTAAA

1361 1371 1381 1391 1401 1411

ALA PRO TRP MET PRO ASP ARG THR GLU ALA ASN PRO ASN GLU LEU ASN GLN ASP ASP ALA

G CGTGGATGCCTGACCGTACCGAGGCTAACCCTAATG A G T TAATCAAGATGATGCT

7 1421 1431 1441 1431 Al/12c 1461 1471

ARB TYR GLY PHE ARG CYS CYS HIS LEU LYS ASN ILE TRP THR ALA PRO LEU PRO PRO GLU

CGTTATGGTTTCCETTGCTGCCATCTCAAAAACA

17
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